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X chromosome inactivation in primates: when, where and why?| title | X chromosome inactivation in primates: when, where and why? |
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| start_date | 2024/06/07 |
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| schedule | 11h |
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| online | no |
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| location_info | Salle de conférence C404 |
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| summary | X chromosome inactivation (XCI) in mammals is an essential epigenetic process which compensates for X chromosome imbalance between sexes. The transcriptional silencing of one of the two X chromosomes is established early during female development, at peri-implantation stages, and is triggered by the accumulation of the long noncoding RNA XIST through mechanisms that begin to be elucidated. This process has been mainly studied in the mouse where embryonic stem cells (ESCs) have been instrumental to characterize the actors of the process, and to unravel the kinetics of the molecular events leading to the transcriptional silencing of one of the two X chromosomes. However, it is now known that X-inactivation initiates through remarkable diverse strategies in different species. We are using primate ESCs and their differentiated derivatives to characterize the timing and mechanisms of X chromosome inactivation and its requirement for early primate development. |
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| responsibles | Carré, Hervé |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2024/05/30 13:48 UTC |
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