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Leveraging tissue engineering approaches to elucidate the health benefits of natural products and mitigate neurodegenerative diseases| title | Leveraging tissue engineering approaches to elucidate the health benefits of natural products and mitigate neurodegenerative diseases |
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| start_date | 2024/03/18 |
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| schedule | 13h30 |
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| online | no |
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| location_info | / |
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| summary | At the core of human existence lies a profound and intricate relationship with the plant world. Throughout our lives, we will rely on plants to breathe, eat, and heal, and Indigenous teachings across the globe recognize sacred properties to culturally symbolic medicinal plants. During this talk, we will explore the traditional and contemporary uses of herbal remedies to promote healthy aging and attenuate symptoms of neurodegenerative disorders. We will discuss conceptual and methodological approaches used in our laboratory to understand the biological mechanisms underlying the pro-health benefits of plant-based natural products. More specifically, our interest lies in the ability of these molecules to promote defense mechanisms in the aging brain by targeting non-neuronal brain cells, as these cell types regulate neuroinflammatory and neurotrophic processes involved in neuron survival. Experimental approaches to address these complex questions rely on cutting-edge technologies, such as induced pluripotent stem cells and the generation of 3D microfluidic and organoids-based modeling platforms. These exciting technologies – and others – hold promises to create more complex disease models that recapitulate the cytoarchitecture and dynamic cell-cell interactions characteristic of the human brain. Applying these tools to natural health product research in aging and neurodegenerative disorders has the potential to facilitate new discoveries and inform on their safety, efficacy and mechanisms of action. |
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| responsibles | Perrais, Thoumine |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2024/03/18 10:27 UTC |
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