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Neuroimmune regulation in the skin: molecular mechanisms and therapeutic perspectives| title | Neuroimmune regulation in the skin: molecular mechanisms and therapeutic perspectives |
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| start_date | 2024/05/31 |
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| schedule | 11h |
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| online | no |
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| location_info | Salle de conférence C404 |
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| summary | The survival of living organisms depends on their ability to develop defence mechanisms to respond to environmental challenges that cause tissue damage and infections. These protective functions involve both the immune system and the nervous system, which have traditionally been considered independent of each other. However, it has recently been shown that the nervous system regulates immune functions. Pain is one of the most important signs of inflammation. After an injury or infection, inflammatory mediators activate nociceptive sensory neurons in tissues. These neurons transmit the signal to the brain, triggering the perception of pain. They also release a number of mediators directly at the site of injury, modulating local immune responses. We have recently shown that a subset of sensory neurons plays a key role in limiting inflammation and promoting macrophage tissue repair functions in the skin. The sensory nervous system also regulates the adaptive immune response to Herpes simplex virus type 1 (HSV-1) infection. We are investigating the molecular and cellular basis of these neuro-immune regulations and the potential therapeutic value of our findings for the treatment of inflammatory diseases. |
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| responsibles | Carré, Hervé |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2024/05/23 15:31 UTC |
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