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Les bases psychologiques et neuronales des habitudes incitatives : pertinence pour notre compréhension de la dépendance| title | Les bases psychologiques et neuronales des habitudes incitatives : pertinence pour notre compréhension de la dépendance |
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| start_date | 2024/09/09 |
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| schedule | (date exacte à venir) |
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| online | no |
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| location_info | Amphithéâtre |
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| summary | Our research is interested in the neural, cellular and molecular substrates of inter- individual vulnerability to develop impulsive / compulsive disorders such as drug addiction or Obsessive – compulsive disorder. Our working hypothesis is that impulses, originating from the amygdalo insular networks can drive the behavior through explicit knowledge involving prefrontal and orbitofrontal loops or implicit mechanisms that instead depend upon the functional relationships of these structures with several domains of the striatum.
We suggest that inter-individual vulnerability to develop impulsive / compulsive neuropsychiatric disorders stem from aberrant plasticity processes within the corticostriatal networks governing the translation of impulses into actions that ultimately result in a so-called abnormal incentive habit process.
Our research is designed according to a vertical, top-down strategy with direct translational perspectives. It stems from a unique combination of contemporary techniques ranging from experimental psychology to causal manipulations of the brain with selective pharmacological tools, DREADDS or optogenetics and,correlational analyses of the brain using state of the art molecular biology and electrophysiology techniques.
Our program is subdivided in several converging lines of research:
1. The role of the insular cortex, and its interactions with the BLA and the ventral striatum, in drug addiction and OCD.
2. The nature of the functional interactions between the amygdala and the striatum subserving the establishment of compulsive incentive habits.
3. The cellular and molecular substrates of intrastriatal shifts subserving incentive habits habits.
4. The influence of the environment on inter-individual differences in the vulnerability to develop impulsive / compulsive disorders. |
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| responsibles | NC |
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