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Dissection of a memory engram to understand how associative memories are formed| title | Dissection of a memory engram to understand how associative memories are formed |
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| start_date | 2024/06/19 |
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| schedule | 11h |
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| online | no |
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| location_info | / |
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| summary | When an associative memory is formed? Which cells represent memories, and when are they engaged? In my laboratory, we are interested inn understanding memory formation and consolidation. To this aim we use techniques to visualize and tag cells with unprecedented temporal precision, to unravel their role in processing specific information present at the time of encoding. I will first show the possibility to implant fully artificial memories in mice just by optogenetically targeting codes the brain uses to process external information. I will then present new data from my lab where we identified non-overlapping dorsal CA1 neuronal ensembles that are differently active during associative fear memory acquisition. These ensembles disproportionately contribute to fear engram formation This study revealed, for the first time, the unique contribution of cells active at specified time points to the formation of a memory trace. |
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| responsibles | NC |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2024/06/11 15:19 UTC |
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