|
Studying axon plasticity: from intracellular dynamics to large-scale rewiring| title | Studying axon plasticity: from intracellular dynamics to large-scale rewiring |
|---|
| start_date | 2024/06/19 |
|---|
| schedule | 14h |
|---|
| online | no |
|---|
| location_info | / |
|---|
| summary | Long regarded as a rigid and aging organ, the adult brain is capable of profound reorganization at the macroscopic level of its cerebral circuits. This emerging concept, known as ‘brain rewiring’, postulates that neural circuits keep restructuring in response to neuronal activity. But what makes axonal rewiring efficient in the adult brain? How is it regulated with experience and learning? Alterations in brain connectivity exist in neurodegenerative diseases, such as Huntington’s disease and Amyotrophic Lateral Sclerosis. Could we reverse engineer the rewiring capacity of the brain to restore dysfunctional networks on-demand? In the lab, we address these burning questions by investigating the molecular and cellular underpinnings of axonal remodeling, using an organ-on-a-chip approach, in health and disease.
In this talk, I will present how brain-on-chip microdevices helped us to discover unexpected intracellular mechanisms regulating axonal remodeling. I will also introduce our latest human-based models and technological development to improve biomedical research. Finally, I will briefly talk about RAIL, a photoinducible technology targeting axon remodeling programs to connect and disconnect neural networks on-demand. |
|---|
| responsibles | NC |
|---|
Workflow history| from state (1) | to state | comment | date |
|---|
| submitted | published | | 2024/06/11 15:26 UTC |
| |
|