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Gliotransmitters and synaptic strength: Permanent alterations in glutamatergic transmission by ATP| old_uid | 55 |
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| title | Gliotransmitters and synaptic strength: Permanent alterations in glutamatergic transmission by ATP |
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| start_date | 2005/10/10 |
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| schedule | 11h30 |
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| online | no |
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| details | invité par Stéphane Oliet |
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| summary | Glial cells actively participate in synaptic transmission. They clear molecules from the synaptic cleft, receive signals from neurons and, in turn, release molecules that can modulate signaling between neuronal elements.
Whether glial-derived transmitters can contribute to enduring changes in postsynaptic efficacy, however, remains to be established.
Analysis of miniature excitatory postsynaptic currents (mEPSCs) in brain slices of the rat hypothalamic paraventricular nucleus (PVN) reveals an enduring increase in the amplitude of these events in response to noradrenaline (NA) that requires the release of ATP from glial cells.
The increase in quantal efficacy, likely resulting from an insertion of AMPA receptors, is secondary to the activation of P2X7 receptors, an increase in postsynaptic calcium and the activation of phosphoinositide.
The gliotransmitter ATP, therefore, contributes directly to the regulation of postsynaptic efficacy at glutamatergic synapses in the central nervous system. |
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| responsibles | Renaud, Deris |
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