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From neural plasticity to memory| old_uid | 227 |
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| title | From neural plasticity to memory |
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| start_date | 2005/11/23 |
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| schedule | 10h |
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| online | no |
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| details | C’est un séminaire exceptionnel présenté par Aline Desmedt avec trois intervenants dans le cadre de la triade Bordeaux-Weizmann Institute- Haïfa University |
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| summary | “The risky life of the memory trace after its reactivation”
The fate of the memory trace after its reactivation in retrieval depends on a number of factors. These include the context of reactivation; the new information encoded in the retrieval session per-se; the time elapsed since the original encoding; and the presence of other, associated traces, which compete with the reactivated trace for the control over behavior. This competition for hegemony results either in memory extinction or in reprocessing of the original trace via a time-limited process termed 'reconsolidation'. Identification of brain mechanisms of memory extinction and reconsolidation may cast light on the nature of memory persistence and retrievability, and lead to the development of novel methods to treat post-traumatic stress disorder (PTSD) and phobia.
“Morphological basis of Neuronal plasticity”
I will describe our experiments on cellular plasticity in cultured hippocampal neurons, where we produce a transient change in network activity that causes long term changes in synaptic connections among neurons in the culture, and a morphological change in dendritic
spines of these neurons. We analyze the cellular and molecular events
underlying these changes.
"Stress and Amygdala modulation of memory-related processes in the hippocampus"
When thinking about stress effects on learning and memory we intuitively think about impairments though it is well established that stressful experiences are often remembered better than neutral events. I will present data indicating that under some conditions stress may enhance performance in a learning task and that stress can activate the amygdala and affect hippocampal plasticity in a region-specific manner. Under the working hypothesis that the amygdala mediates some of the effects of stress, we further examined the effects of amygdala activation on hippocampal plasticity. Similarly to stress, amygdala activation was found to affect hippocampal LTP in a region-specific manner. The results support the view that stress effects on hippocampal dependent learning is mediated by stress activation of the amygdala. |
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| oncancel | Attention changement de lieu |
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| responsibles | Renaud, Deris |
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