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The anatomofunctional organization of orthographic and phonological working memory systems : neurological and fMRI data| old_uid | 1131 |
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| title | The anatomofunctional organization of orthographic and phonological working memory systems : neurological and fMRI data |
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| start_date | 2006/04/28 |
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| schedule | 12h |
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| online | no |
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| summary | Several neuropsychological and neuroimaging studies propose a left-lateralized neural network including frontal (MFG and IFG) and parietal (IPS) structures as the most likely anatomical basis of phonological working memory (e.g., Smith & Jonides, 1998; Chafey & Goldman-Rakic, 2000).
We conducted two studies of orthographic working memory. The first included 4 subjects with acquired dysgraphia and damage to orthographic working memory (the graphemic buffer) but normal phonological working memory. The second was an fMRI experiment on cognitively unimpaired participants that required normal orthographic working memory capacity. Both lesion analysis in the first study and activation data in the second demonstrated the involvement of the left fronto-parietal network – precisely the network considered by current hypotheses to provide the anatomical underpinnings of phonological working memory.
The apparent discrepancy between neurological and fMRI observations can be accounted for by assuming that, contrary to current hypotheses, the left fronto-parietal network thought to provide the neural basis of phonological working memory actually corresponds to a modality-independent working memory system, one that receives phonological or orthographic content from modality-specific structures located in the temporal and in the frontoparietal structures of the left hemisphere, respectively. |
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| responsibles | Seror, Bartolomeo |
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