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Curing post-traumatic stress disorder by targetting reconsolidation of their traumatic memories| old_uid | 1502 |
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| title | Curing post-traumatic stress disorder by targetting reconsolidation of their traumatic memories |
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| start_date | 2006/07/03 |
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| schedule | 11h30 |
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| online | no |
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| details | Invité par Aline Desmedt (CNRS UMR 5106, Université Bordeaux 1) |
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| summary | Memory consolidation theory posits that new memories initially enter a labile or sensitive state during which they can be disrupted called short term memory (STM). Over time this STM is converted to a “fixed” long-term memory (LTM) that is resistant to being disrupted. In order for memories to enter LTM, the neurons mediating the memory must produce new proteins that will be used for the long-term storage of the memory.
Recently, we showed that when a consolidated LTM is remembered or reactivated, it returns to a labile state similar to STM in that neurons must synthesize new proteins in order for the memory to persist. If protein synthesis is inhibited after reactivation of a consolidated auditory fear memory, that memory was impaired. This phenomenon is called Reconsolidation. The findings from my studies have significant clinical implications for memory disorders such as post-traumatic stress disorder (PTSD). At a theoretical level, reconsolidation can provide a mechanistic basis to explain the dynamic nature of memory. |
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| responsibles | Renaud, Deris |
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