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Cannabinoids dirsupt synchrony and spatial representation in the
hippocampus| old_uid | 1503 |
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| title | Cannabinoids dirsupt synchrony and spatial representation in the
hippocampus |
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| start_date | 2006/07/03 |
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| schedule | 11h |
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| online | no |
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| location_info | salle 1 |
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| summary | In the intact hippocampus, temporal coordination of excitatory and inhibitory synaptic potentials supports at least three types of network activity, including theta (4-12 Hz), gamma (30-80 Hz) and ripple (120-200 Hz) oscillations. It has been hypothesized that theta/gamma oscillations are involved in memory encoding and plasticity, whereas the fast ripple oscillations are critical for the transfer of information
from the hippocampus to the neocortex. However, it remains largely unknown how the coordination of hippocampal cell assemblies gives rise to these network patterns and supports mnemonic functions of the hippocampus. Here, we show that cannabinoids disrupt the temporal coordination of hippocampal neurons and deteriorate theta, gamma and ripple network patterns without substantial changes in principle cell and interneuron average firing rates. These data suggest that the
amnesic effects of marijuana are produced by disrupting the temporal coordination of hippocampal cell assemblies critical for normal hippocampal function. |
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| responsibles | <not specified> |
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