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Plasticity-Stability Balance in Neural Circuits: From Activity Homeostasis to Alzheimer’s Disease| title | Plasticity-Stability Balance in Neural Circuits: From Activity Homeostasis to Alzheimer’s Disease |
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| start_date | 2024/09/20 |
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| schedule | 11h30 |
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| online | no |
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| location_info | / |
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| summary | Understanding how neurons and neural networks, composed of highly dynamic molecules with relatively short half-lives, maintain stable firing properties remains one of the most intriguing questions in neuroscience. Since the time of Claude Bernard, scientists have been striving to uncover the fundamental principles and molecular mechanisms that underlie homeostasis at the cellular, network, and system levels. Despite significant advances, the mechanisms that enable network-wide resilience of activity patterns remain largely unknown. In this talk, I will explore the cellular and network properties regulated by homeostatic systems, the spatial scale of this regulation, and the mechanisms behind set-point control. Furthermore, I will present evidence suggesting that activity dyshomeostasis begins during low-arousal brain states, such as anesthesia and sleep, at the presymptomatic stage in familial Alzheimer’s disease models. Finally, I will propose a model linking activity dyshomeostasis, sleep disturbances, and memory dysfunctions in Alzheimer’s disease, and present circuit-wide mechanisms that may restore this dysregulation. |
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| responsibles | NC |
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Workflow history| from state (1) | to state | comment | date |
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| submitted | published | | 2024/09/12 12:09 UTC |
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