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The effect of combined administration of atypical antipsychotics and selective serotonin reuptake inhibitors on the firing activity of serotonin and norepinephrine neurons| old_uid | 1707 |
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| title | The effect of combined administration of atypical antipsychotics and selective serotonin reuptake inhibitors on the firing activity of serotonin and norepinephrine neurons |
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| start_date | 2006/11/07 |
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| schedule | 11h30 |
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| online | no |
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| details | Invité par Umberto Spampinato |
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| summary | The atypical antipsychotics risperidone and olanzapine were previously shown to reverse the escitalopram-induced inhibition of NE neuronal firing activity. Thus, non-response to SSRIs in some patients may be explained by a decreased NE tone and the beneficial effect of atypical antipsychotics by its reversal. Using in-vivo electrophysiology in laboratory rats, it was found that paliperidone (the 9-OH metabolite of risperidone) reversed the escitalopram-induced suppression of NE neuronal firing, as it was observed for risperidone. The acute administration of risperidone produced a robust inhibition of firing of 5-HT neurons. This inhibition was partially reversed by the NE reuptake inhibitor desipramine or by the 5-HT1A antagonist WAY 100635 and completely reversed when both WAY 100635 and desipramine were given. However, paliperidone did not alter the firing rate of 5-HT neurons. Paliperidone, as observed with risperidone. The capacity of paliperidone to reverse the SSRI-induced inhibition of NE neuronal firing rate, without decreasing of 5-HT neuronal activity, suggests that paliperidone may be beneficial in SSRI-resistant depression. |
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| responsibles | Deris |
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