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Rule-based decision making in the frontal lobe revealed by a novel ocular baseball task| old_uid | 2622 |
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| title | Rule-based decision making in the frontal lobe revealed by a novel ocular baseball task |
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| start_date | 2007/04/06 |
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| schedule | 11h-12h |
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| online | no |
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| location_info | bt. 9, rdj/ouest-08, salle de cours |
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| summary | How does the brain convert sensory information into motor decisions based on abstract rules? In a series of studies, we adopted a novel "ocular baseball" task to tease apart the distinct roles different frontal regions play in orchestrating rule-based oculomotor control. Human functional imaging was conducted to isolate frontal regions involved in the task, including the supplementary eye field (SEF), the frontal eye field (FEF), and the ventrolateral prefrontal cortex (VLPFC). We then recorded single-unit activity from these regions of macaque monkeys to determine their specific functions. From this data, it appears that the SEF participates in evaluating sensory information, as well as in encoding an arbitrary movement deadline, according to the rules. The FEF on the other hand, encodes the actual movement decision but is less involved in rule evaluation. Preliminary data recorded from the VLPFC reveals that this structure is involved in monitoring behavioral errors in relation to the rule. Our results suggest that different frontal regions are recruited to execute different components of rule-based sensorimotor control. These results should help establish a hierarchy of primate frontal cortex in higher-order cognitive functions. |
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| responsibles | Pélissier, Grainger |
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