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Synaptic Theory of Working Memory| old_uid | 3648 |
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| title | Synaptic Theory of Working Memory |
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| start_date | 2007/12/10 |
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| schedule | 16h15 |
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| online | no |
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| summary | It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here we propose a new theoretical framework whereby working memory is sustained by calcium mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a 'buffer' which is loaded, refreshed and read-out by spiking activity. Due to the long time constants of calcium kinetics, the refresh rate can be very low, which results in a mechanism that is metabolically efficient
and resistant to external interferences. The duration and stability of working memory can be effectively regulated by modulating the spontaneous activity in the network. |
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| responsibles | van Vreeswijk, Hansel |
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