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Biophysics of Computation : Roles of Shunting Inhibition and Membrane Channels in Neuronal Processing and Visual Receptive Fields| old_uid | 4258 |
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| title | Biophysics of Computation : Roles of Shunting Inhibition and Membrane Channels in Neuronal Processing and Visual Receptive Fields |
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| start_date | 2008/03/11 |
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| schedule | 11h-12h30 |
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| online | no |
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| summary | The quantitative and qualitative roles of specific biophysical mechanisms in neural information processing, including synaptic dynamics and intrinsic membrane properties, is a fundamental question in computational systems neuroscience. We are addressing this using in vivo intracellular (whole cell patch) recordings, closely tied with detailed cellular models, to characterize the basic input-output properties of cortical neurons and, in visual cortex, the expression of receptive fields. With voltage clamp protocols, we establish the relationship between excitatory and inhibitory synaptic input and spike output. With dynamic clamp protocols, we characterize how mechanisms including shunting synaptic inhibition, the fast potassium current I_BK and the persistent sodium current I_NaP affect basic neuronal properties, to understand how they might contribute to visual responses and coding. I will present a survey of our findings including the non-linear versus linear impact of shunting inhibition on neuronal input/output, response acceleration by I_BK, and reduction of firing gain by I_NaP. |
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| oncancel | exceptionnellement un mardi |
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| responsibles | Information non disponible |
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