|
Cell migration in heterogeneous media and applications to cancer modeling| old_uid | 5246 |
|---|
| title | Cell migration in heterogeneous media and applications to cancer modeling |
|---|
| start_date | 2008/09/05 |
|---|
| schedule | 10h |
|---|
| online | no |
|---|
| summary | Cell migration through tissues is an essential feature of, either physiologic or pathologic, phenomena in biology, such as embryonic development, wound healing or tumor invasion. Cells (cancer metastases, fibroblasts, etc.) interact both with other cells and with the surrounding tissue (the ExtraCellular Matrix) which provides them a natural complex scaffold to adhere to during motion.
Here we look closer at the individual interaction mechanisms to derive a kinetic (mesoscopic) model that includes both a preferential movement of cells along the collagen fibres of the ECM (contact guidance) together with a randomly oriented motion due to the interactions among cells. The response of the cells to external stimuli (taxis) capable of influencing and biasing the motion is also included.
The continuous (macroscopic) model is deduced through a diffusive limit of the kinetic one. Numerical simulations are presented to illustrate the ability of the model to account for the influence of (a) the heterogeneity and/or the anisotropy of the ECM medium and (b) various sorts of taxis (chemotaxis, haptotaxis, repellent behaviour).
In a second part, we present how the previous approach can be extended to integrate specific mechanisms relating to tumor invasion. Attention is focused on the ability of cells to change their migratory behaviour (phenotype). According to the phenomenology observed in solid brain tumor, a “Go or Rest” model is derived and presented. |
|---|
| responsibles | Bourgine |
|---|
| |
|