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VEGF-C/VEGFR-3 signaling in inerneuronal birth, or when neural cells make use of vascular growth factors| old_uid | 6743 |
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| title | VEGF-C/VEGFR-3 signaling in inerneuronal birth, or when neural cells make use of vascular growth factors |
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| start_date | 2009/04/16 |
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| schedule | 12h |
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| online | no |
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| details | Invité par Uwe Maskos, tél. 01 45 68 88 06, e-mail: umaskos@pasteur.fr |
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| summary | In the vascular system, VEGF-C specifically regulates lymphangiogenesis by binding and signaling through the tyrosine kinase receptor VEGFR-3. VEGFR-3 expression is largely restricted to lymphatic endothelial cells but also detectable in the central nervous system (CNS) that is devoid of lymphatics. Here, we report the contribution of VEGF-C/VEGFR-3 signaling to postnatal neurogenesis. Using Vegfc-and Vegfr3-lacZknockin neonates,we show that Vegfr3+ interneurons arise in the septum, striatum, cortex and olfactory bulb during the two first neonatal weeks. They derive from the subventricular zone (SVZ) of the lateral ventricles, where Vegfr3+ neural precursors are initially localized adjacent to VEGF-C expressing ependymal cells and neuroblasts. Neurosphere assays show that VEGF-C promotes survival of Vegfr3+ neuroblasts and their differentiation into inhibitory interneurons. In vivo VEGF-C overexpression in the neonatal and adult forebrain promotes neurogenesis but not angiogenesis. Thus, VEGF-C/VEGFR-3 signaling promotes production of inhibitory interneurons, suggesting that this lymphangiogenic growth-factor-receptor system may contribute in the CNS to the establishment of behavior. |
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| responsibles | Baran |
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