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Invertebrate and vertebrate models of the neurobiology of nicotine motivation| old_uid | 6832 |
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| title | Invertebrate and vertebrate models of the neurobiology of nicotine motivation |
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| start_date | 2009/04/30 |
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| schedule | 12h |
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| online | no |
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| location_info | bât. Metchnikoff, salle Jules Bordet |
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| summary | A new invertebrate model of nicotine motivation in the worm C.elegans will be presented. This is a promissory note suggesting that the cellular and genetic expertise in this organism can reveal new players in nicotine motivation. Work on the motivational effects of nicotine in rodents have lead to a more mature model of the nicotine motivational circuit in mammals. Within the ventral tegmental area of the midbrain, dopamine neurons mediate the aversive effects of acute nicotine exposure, while GABA neurons mediate the rewarding effects. The interactions of these two cells types provide an explanation for the unusual dose response curve for the motivational effects of nicotine in previously nicotine naive animals. In nicotine dependent and withdrawn animals, the motivational effects are mediated by dopamine neurons. |
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| responsibles | Baran |
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