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Inhibition and the speed of odor discrimination in mice| old_uid | 7334 |
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| title | Inhibition and the speed of odor discrimination in mice |
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| start_date | 2009/09/11 |
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| schedule | 14h30 |
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| online | no |
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| location_info | amphi G2 |
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| summary | Local inhibitory circuits are thought to shape neuronal information processing in the central nervous system, but it remains unclear how specific properties of inhibitory neuronal interactions translate into behavioral performance. In the olfactory bulb, inhibition of mitral/tufted cells via granule cells may refine neuronal representations of odors, which has been speculated to underlie odor discrimination behavior. Here we show that selective deletion of the AMPA receptor subunit GluA2 in granule cells boosted synaptic Ca2+ influx, thereby increasing inhibition of mitral cells in vitro and in vivo. On a behavioral level, this resulted in accelerated discrimination of similar odor mixtures while leaving learning and memory unaffected. Selective removal of NMDA receptors in granule cells slowed discrimination of similar odors. Our results demonstrate that inhibition of mitral cells controlled by granule cell glutamate receptors results in fast and accurate discrimination of similar odors. Thus, spatio-temporally defined molecular perturbations of olfactory bulb granule cells directly link stimulus-similarity, neuronal processing time and discrimination behavior to synaptic inhibition. |
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| responsibles | Gervais |
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