|
Vagal sensory neurons and energy balance| old_uid | 9942 |
|---|
| title | Vagal sensory neurons and energy balance |
|---|
| start_date | 2011/05/09 |
|---|
| schedule | 11h30 |
|---|
| online | no |
|---|
| summary | Sensory neurons of the vagus nerve (located in the nodose ganglion) are potentially key integrators of changing levels of metabolic cues. In fact, vagal sensory neurons innervate key metabolic visceral organs including the liver, pancreas, and gastrointestinal tract. Moreover, accumulating evidence suggests that the vagus nerve serves as a critical link between changing energy availability and coordinated control of glucose homeostasis and energy balance. Thus, many investigators acknowledge that identifying the mechanisms and pathways underlying the integration of vagal information is a true challenge geared toward the fight against obesity and metabolic disorders. I'm particularly interested in investigating the physiological role of vagal sensory neurons in the intact mouse using unique transgenic models that allow manipulation of gene expression in the nodose ganglion. In my talk, I will discuss the key role played by specific populations of afferents in the regulation of lipid metabolism and intestinal inflammation. I will also outline a number of our recent studies utilizing mouse genetic, neuroanatomy, metabolic physiology and molecular profiling. Our results will be discussed in the context of the role played by the vagus nerve in metabolic disorders and anti-obesity therapies. |
|---|
| responsibles | Deris |
|---|
| |
|