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Glial contribution to neuronal activity and plasticity| old_uid | 10118 |
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| title | Glial contribution to neuronal activity and plasticity |
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| start_date | 2011/07/11 |
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| schedule | 09h30 |
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| online | no |
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| location_info | locaux de l’équipe J. Honnorat |
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| details | conférence animée par l’équipe Jérôme Honnorat |
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| summary | Motivational value depends upon multiple parameters including the size of the reward, the cost of obtaining it, or the internal state of the subject. This value drives a variety of behaviors, ranging from appetitive reflexes to more elaborate, goal directed actions. To understand the neuronal processes by which value information drives behavioral responses, we recorded the activity of single neurons in behaving monkeys. Animals performed simple tasks enabling us to compare the influence of reward value on appetitive Pavlovian reflexes and goal-directed actions. A first set of experiments was aimed at comparing the contribution of the ventromedial and orbitofrontal cortices to the assessment of motivational value. Another set of experiments was designed to understand the role of the noradrenergic nucleus locus coeruleus in motivational processes, and the extent to which this role differs from that of dopaminergic neurons from the substantia nigra.
This work provides new insights into the neuronal mechanisms underlying the regulation of motivation as a function of the reward’s value. |
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| responsibles | Béranger, Rossetti |
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