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Time-frequency measures of EEG and intracranial data during cognitive control and reward anticipation| old_uid | 10134 |
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| title | Time-frequency measures of EEG and intracranial data during cognitive control and reward anticipation |
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| start_date | 2011/09/05 |
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| schedule | 14h-15h |
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| online | no |
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| location_info | salle 01/02 |
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| summary | The nucleus accumbens and medial frontal cortex (MFC) are part of a loop involved in modulating behavior according to anticipated rewards. However, the precise temporal landscape of their electrophysiological interactions in humans remains unknown because it is not possible to record neural activity from the nucleus accumbens using non-invasive techniques. Here I will provide an overview of our work measuring electrophysiological activity simultaneously from the nucleus accumbens and cortex (via surface EEG) in humans who had electrodes implanted as part of deep-brain-stimulation treatment for obsessive-compulsive disorder. We find that “top-down” directed synchrony from cortex to nucleus accumbens is maximal over medial frontal sites, and significantly stronger when patients anticipate receiving rewards. Additional experiments confirm that these interactions take place within the theta-frequency band, which is often associated with memory and cognitive control processes. Studying interactions between the medial frontal cortex and nucleus accumbens are not limited to patients with implanted electrodes; surface EEG can be combined with structural MR imaging to reveal that subjects with stronger anatomical connectivity linking the medial frontal cortex to the ventral striatum have stronger cortical theta-band activity during cognitive control tasks. These findings provide both direct and indirect electrophysiological evidence for a role of the medial frontal cortex in modulating nucleus accumbens activity during reward processing and cognitive control. |
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| responsibles | <not specified> |
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