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A surprising role for glial phagocytosis in prion-like transmission of polyglutamine aggregates in the Drosophila olfactory system| old_uid | 10160 |
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| title | A surprising role for glial phagocytosis in prion-like transmission of polyglutamine aggregates in the Drosophila olfactory system |
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| start_date | 2015/11/23 |
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| schedule | 11h |
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| online | no |
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| details | Conférence de l'ICM. Invité par Olga Corti. |
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| summary | Fibrillar protein aggregates are prominent pathological features of neurodegenerative disease and these aggregates can contribute to lateral spread of disease pathology by propagating along neuronal tracts in a prion-like fashion. The brain has a limited capacity to protect itself against aggregate-associated pathology, and mounting evidence supports a role for phagocytic glia in this process. I will present recent data from a new Drosophila model that we have generated to investigate the mechanism by which polyglutamine protein aggregates propagate between synaptically connected neurons in the intact brain. |
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| responsibles | Oliviero |
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