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From fear conditioning to decision-making: anxiety-related impairments in processing information within aversive environments| old_uid | 10248 |
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| title | From fear conditioning to decision-making: anxiety-related impairments in processing information within aversive environments |
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| start_date | 2015/12/15 |
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| schedule | 11h30-13h |
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| online | no |
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| summary | The ability to track and update stimulus-stimulus and action-outcome contingencies is central to both the acquisition and extinction of conditioned fear and to reinforcement learning. While the fear conditioning literature has focused on associative learning using aversive unconditioned stimuli, the decision-making literature has primarily investigated the effects of varying schedules of reward. There is however evidence that anxiety is not only linked to enhanced acquisition and maintenance of conditioned fears but also to altered decision-making. The work presented examines the extent to which trait vulnerability to anxiety is associated with altered processing of contingencies in aversive environments, both using classical Pavlovian fear conditioning and an aversive learning task requiring decision making under threat of shock. FMRI and pupillometry are used to characterise the mechanisms disrupted. In addition, traditional models from the reinforcement learning literature are combined with more recent Bayesian approaches to examine the aspects of decision making altered in high trait anxious individuals. |
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| responsibles | Sackur |
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