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The Good, the Bad, and the Ugly in study of cortico-cortical connectivity| old_uid | 10845 |
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| title | The Good, the Bad, and the Ugly in study of cortico-cortical connectivity |
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| start_date | 2012/02/10 |
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| schedule | 11h-12h |
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| online | no |
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| summary | During the last 10 years we have studied cortico-cortical connectivity with magnetoencephalography (MEG) using various approaches. I will first describe the basic methodology (Dynamic Imaging of Coherent Sources, DICS; event- related DICS, erDICS) we have developed and applied and show, e.g., how field spread issues affect the validity of the obtained estimates. I will then present a number of approaches, based on DICS and erDICS, we have used to identify and characterize cortico-cortical networks in both motor and reading tasks. Furthermore, I will discuss the good, the bad, and the ugly aspects of each approach as well as the additional information the network analyses have yielded compared to methods based solely on neural activity. I will also describe how directed interaction measures, namely Granger Causality, can be applied in identification of epileptogenic networks using both intracranial and MEG recordings.
Key references:
[1] Gross J, Kujala J, Hämäläinen M, Timmermann L, Schnitzler A, Salmelin R. Dynamic imaging of coherent sources: Studying neural interactions in the human brain. PNAS 2001; 98: 694-9.
[2] Gross J, Timmermann L, Kujala J, Dirks M, Schmitz F, Salmelin R, Schnitzler A. The neural basis of intermittent motor control in humans. PNAS 2002; 99: 2299-302.
[3] Kujala J, Pammer K, Cornelissen PL, Roebroeck A, Formisano E, Salmelin R. Phase Coupling in a Cerebro-cerebellar Network at 8-13 Hz during Reading. Cerebral Cortex 2007;17:1476-1485.
[4] Kujala J, Vartiainen J, Laaksonen H, Salmelin R. Neural interactions at the core of phonological and semantic priming of written words. Cerebral Cortex. In press. |
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| responsibles | Pélissier |
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