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How to build a dynamic meiotic spindle in five easy steps| old_uid | 11259 |
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| title | How to build a dynamic meiotic spindle in five easy steps |
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| start_date | 2012/04/10 |
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| schedule | 17h |
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| online | no |
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| location_info | 1er étage, salle 28 132 |
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| summary | The vertebrate meiotic spindle is routinely studied using extracts prepared from the eggs of Xenopus frogs. In these extracts, thousands of microtubules are nucleated around the chromatin mass, and with time organize into a functional bipolar spindle. Remarkably, at metaphase a spindle can remain essentially unchanged for hours, despite the fact that the individual microtubules from which it is made have a lifetime of one minute. The spindle is thus a steady state assembly of dynamic components. Using simulations, we will introduce the key ingredients necessary to understand spindle dynamics: molecular motors, poleward flux, microtubule dynamic instability, nucleation and depolymerizing enzymes. We will illustrate how these elements are logically linked and then show how they collectively give rise to the metaphase steady state. We will finally present the advantages that such an organization can offer. |
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| responsibles | Longo, Mossio, Barandiaran |
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