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Human subthalamic neurons encode executive control in patients with obsessive compulsive disorder| old_uid | 11560 |
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| title | Human subthalamic neurons encode executive control in patients with obsessive compulsive disorder |
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| start_date | 2012/06/25 |
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| schedule | 11h30 |
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| online | no |
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| location_info | 452, Bibliothèque |
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| details | Conférence CRNL-DYCOG, Equipe Dynamique cérébrale et Cognition - Dir O. Bertrand |
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| summary | Anxious intrusive thoughts and repetitive behaviour experienced by patients with obsessive compulsive disorder (OCD) are hypothesized to reflect dysfunctions of the associative-limbic cortico-basal ganglia loops (Saxena et al., 1998; Schall et al., 2002; Chamberlain et al., 2005; Endrass et al., 2008). Here we studied whether subthalamic nucleus (STN) neurons, which are known to show abnormal baseline activity in OCD (Piallat et al., 2011), are also involved during inhibitory control in humans, as predicted by non-human primate recordings (Isoda and Hikosaka, 2008). Electrophysiological recordings of STN were performed in seven severe OCD patients treated with STN deep brain stimulation (DBS) (Mallet et al., 2008; Piallat/ et al./, 2011). Patients performed a stop-signal task that investigates the control of thought and action by probing their ability to withhold a planned movement in response to an infrequent countermanding signal (Logan et al., 1984). Per-operative recordings of STN neurons revealed the existence of three functionally distinct neuronal populations: one group of neurons responded to motor execution, another class of cells was involved during successfully stopped responses and a third, unexpected type of neurons increased its firing rate only after behavioural errors. Post-operative local field potentials recordings showed a decrease of activity in the beta band (15-30 Hz) during motor execution and an increase during motor inhibition. Altogether, these data demonstrate that human STN can encode two executive control functions (Stoet and Snyder, 2009), inhibitory control and monitoring of the consequences of actions. The STN could thus be an important component of frontally driven executive control (Baunez and Lardeux, 2011). |
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| responsibles | Béranger, Rossetti |
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