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Dopaminergic modulation of timing in basal ganglia and SMA| old_uid | 11762 |
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| title | Dopaminergic modulation of timing in basal ganglia and SMA |
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| start_date | 2012/10/25 |
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| schedule | 10h30-12h |
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| online | no |
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| location_info | salle de réunion de l’UFR |
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| summary | Functional neuroimaging has consistently identified a core timing network, comprising basal ganglia, Supplementary Motor Area (SMA) and right prefrontal cortex. In parallel, psychopharmacological studies in animals and humans have shown that timing can be perturbed by modulation of dopaminergic function. By combining fMRI with psychopharmacological techniques, we can pinpoint the elements of the core timing network that are modulated by dopamine and thereby result in an altered sense of time. We have found that dopaminergic manipulation modulates activity in basal ganglia and SMA during initial encoding of stimulus duration but has no effect on prefrontal mediation of timing processes. These data not only identify the neuroanatomical substrates of the neurochemical modulation of timing, but also provide some cognitive insight into the stage of temporal information processing affected by dopamine. |
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| responsibles | Hoffmann, Marin |
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