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Molecular mechanisms underlying memory consolidation and its possible implications for Alzheimer disease new therapy"| old_uid | 11966 |
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| title | Molecular mechanisms underlying memory consolidation and its possible implications for Alzheimer disease new therapy" |
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| start_date | 2012/12/20 |
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| schedule | 10h30 |
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| online | no |
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| location_info | salle de conférence CGFB |
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| details | Une invitation de Guillaume Ferreira de NutriNeuro. |
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| summary | Very little is known about drugs which can enhance the consolidation phase of memories in the cortex, the brain structure considered to store at least partially, long term memories. We tested the hypothesis that pharmacological and genetic manipulation of translation machinery, known to be involved in the molecular consolidation phase, enhances positive or negative forms of cortical dependent taste memories. We found that dephosphorylation (Ser51) of eIF2 ± specifically in the cortex is both correlated and necessary for normal memory consolidation. In order to reduce eIF2 ± phosphorylation and improve memory consolidation, we pharmacologically inhibited the different eIF2 ± kinases. In addition, we tested the involvement of eIF2 ± and PKR in mice models of aging and sporadic Alzheimer disease. |
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| responsibles | Deris |
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