|
Excitatory and inhibitory interactions from rat to human cortex during wake and sleep| old_uid | 12298 |
|---|
| title | Excitatory and inhibitory interactions from rat to human cortex during wake and sleep |
|---|
| start_date | 2013/04/08 |
|---|
| schedule | 11h |
|---|
| online | no |
|---|
| summary | High-density intracranial recordings using either tetrodes or Utah-arrays give access to recordings of large populations of units. Using computational methods, it is possible to separate between regular-spiking (RS) and fast-spiking (FS) neurons. In rats, the RS-FS separation revealed that FS cells fire phasically during sleep spindles, while RS cells seemed less affected by the oscillation. These results are in agreement with previous intracellular recordings in cats and computational models which revealed a very strong inhibition during spindles. In human recordings, it was possible to functionally identify the excitatory or inhibitory character of the units from pairwise correlations, and there was a 100% match with RS and FS cells, respectively. Based on this separation, we found that the correlation pattern between RS pairs differs from FS pairs, and surprisingly, only the latter displayed long-range correlations. There was a tight balance between excitatory and inhibitory activities, for all wake and sleep states, with a notable exception during epileptic seizures. Interestingly, inhibition was not necessarily toned down during the seizure, but to the contrary, FS cells increased their activity while RS cells decreased. We conclude that to correctly understand extracellular recordings, it is necessary to distinguish excitatory from inhibitory cell activities. |
|---|
| responsibles | Miles |
|---|
| |
|