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Plasticity of intrinsic neuronal ixcitability in hippocampal neurons| old_uid | 12585 |
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| title | Plasticity of intrinsic neuronal ixcitability in hippocampal neurons |
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| start_date | 2013/06/10 |
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| schedule | 11h |
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| online | no |
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| summary | In most neurons, information is transmitted to the postsynaptic neuron as discrete amounts of neurotransmitter released by the presynaptic neuron in an all-or-none or digital mode. However, subthreshold activity in the presynaptic element also determines the flow of neuronal information in an analog mode. In the first part of my talk, I will discuss recent results showing two modes of analog-digital enhancement of synaptic transmission at excitatory connections established between CA3 pyramidal neurons. Synaptic plasticity such as LTP and LTD is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ionic channels also participates to information storage. This plasticity may occur in the dendrites but recent results also indicate that voltage-gated ion channels might be regulated in the axon. In this latter case, it generally corresponds to homeostatic plasticity (i.e. compensatory plasticity). Intrinsic plasticity has been reported in principal cells but the contribution of voltage-gated channels in the adaptation of inhibitory circuits remains unclear. In the second part of my talk, I will discuss a form of long-lasting potentiation in intrinsic plasticity in a subset of hippocampal GABAergic interneurons (Campanac et al., Neuron 2013). This plasticity can be considered as homeostatic for hippocampal circuits and involves the regulation of Kv1 channels located in the axon and the cell body. |
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| responsibles | Miles |
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