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The human histaminegic system in health and neuropsychiatric disorder brain| old_uid | 12762 |
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| title | The human histaminegic system in health and neuropsychiatric disorder brain |
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| start_date | 2013/09/12 |
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| schedule | 13h30 |
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| online | no |
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| location_info | salle de conférence |
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| details | Conférence CRNL-WAKING |
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| summary | Histaminergic neurons are exclusively located in the tuberomamillary nucleus (TMN) of the posterior hypothalamus, where histidine decarboxylase (HDC), the rate-limiting enzyme for the synthesis of histamine, is expressed. The neuronal histaminergic system is involved in a number of basic physiological functions, such as the sleep-wake cycle, energy and endocrine homeostasis, sensory and motor functions, cognition, attention, learning and memory, all of which are affected in neuropsychiatric disorders. We will discuss the alterations the histamine system production to the metabolism mainly on the basis of our recent postmortem findings in neuropsychiatric disorders, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), depression, schizophrenia. Special attention is given to the novel histamine-3-receptor antagonists/inverse agonists that are in the process of being introduced into the clinic as potential new treatments for AD, PD, schizophrenia and narcolepsy. |
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| responsibles | Béranger, Rossetti |
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