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Exploring Short-term Synaptic Plasticity: Does Biophysics Help to Understand Synaptic Function| old_uid | 12836 |
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| title | Exploring Short-term Synaptic Plasticity: Does Biophysics Help to Understand Synaptic Function |
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| start_date | 2013/10/04 |
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| schedule | 11h30 |
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| online | no |
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| location_info | 1er étage, Amphi Weiss |
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| summary | The Calyx of Held - a glutamatergic giant nerve terminal in the auditory pathway - is large enough, that presynaptic whole-cell recordings can be performed with excellent control over voltage and the ionic milieu. This allows one to perform a multitude of ‘biophysical’ studies, such as determination of release rates as a function of [Ca++] using caged-Ca, or estimation of the release-ready pool of vesicles and its dynamics. Here, I will summarize such studies and address the question, in how far this information is useful to predict the short-term plasticity features, as observed postsynaptically when stimulating the afferent fiber of an unperturbed Calyx. It turns out, that a precise description of short-termfacilitation and –depression, as well as of its recovery requires a model, which is substantially more complex, than anticipated. |
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| responsibles | Drouet, Martin |
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