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AAV-alpha-synuclein: a new tool to study Parkinson’s disease| old_uid | 13018 |
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| title | AAV-alpha-synuclein: a new tool to study Parkinson’s disease |
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| start_date | 2013/11/15 |
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| schedule | 11h30 |
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| online | no |
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| details | Séminaire FBN. Une invitation d’Erwan Bézard, directeur de l'IMN |
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| summary | Histological and genetic observations strongly suggest a key role of alpha-synuclein in Parkinson’s disease (PD) pathology. Based on these evidences, we have generated a novel model of PD that replicates essential features of the human condition, i.e the progressive loss of nigral dopamine neurons and the presence of alpha-synuclein pathology. This pre-clinical model is thereby an interesting tool to study stage-dependent pathogenic mechanisms and identify possible targets for therapeutic interventions. The seminar will give an overview of this in vivo model and will show how alpha-synuclein can interfere with key transcription factors to disrupt major survival pathways. |
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| responsibles | Deris |
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