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Function of Parkin and PINK1 in mitochondrial quality-control| old_uid | 13045 |
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| title | Function of Parkin and PINK1 in mitochondrial quality-control |
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| start_date | 2013/11/21 |
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| schedule | 11h |
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| online | no |
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| location_info | salle 01-02 |
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| details | Séminaire Axe I - Maladies neurodégénératives |
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| summary | Dr. Edward Fon is a neurologist and scientist who serves as the Director of the McGill Parkinson Program, a National Parkinson Foundation Centre of Excellence. His research focuses on the molecular events leading to the degeneration of dopamine neurons in Parkinson's disease. In the past decade, several genes have been identified that cause some forms of the disease. He is particularly interested in how these genes come together and interact to cause Parkinson's disease. One of his major research interests is the gene encoding the ubiquitin-protein ligase Parkin, which functions as a key enzyme in the main protein degradation pathway in the cell. This pathway utilizes ubiquitin, to mark proteins and target them for degradation. However, ubiquitylation is a versatile post-translational modification that can also regulate protein function. Dr. Fon’s laboratory works on understanding the various functions of ubiquitin in the nervous system and on how defects in Parkin could lead to Parkinson’s disease. |
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| responsibles | Agid |
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