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Deciphering neural circuits of learned direction in Drosophila| old_uid | 13046 |
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| title | Deciphering neural circuits of learned direction in Drosophila |
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| start_date | 2013/11/21 |
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| schedule | 12h15 |
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| online | no |
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| location_info | Bât. 4R3, salle de séminaires du CBD |
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| summary | In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the ab neurons, revealing a value-specific role for the ~160ab core (abc) neurons. Blocking neurotransmission from ab surface (abs) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking abc only impaired appetitive memory. The abc were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate abc and abs in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the ab ensemble but only from theabs for conditioned aversion. |
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| responsibles | Rampon |
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