|
Impact of sleep loss and circadian misalignment on diabetes risk| old_uid | 13195 |
|---|
| title | Impact of sleep loss and circadian misalignment on diabetes risk |
|---|
| start_date | 2013/12/16 |
|---|
| schedule | 11h |
|---|
| online | no |
|---|
| location_info | esc. C, 3e étage, salle de réunion équipe Lin |
|---|
| details | Conférence CRNL-WAKING |
|---|
| summary | Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In laboratory studies of healthy adults, sleep restriction without circadian misalignment promotes insulin resistance and inflammation. Whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse cardio-metabolic effects independently of sleep loss remains an open question. A laboratory study using two protocols of similar sleep restriction, one without and one with circadian misalignment, demonstrates that insulin sensitivity decreases with sleep loss and that the effect of sleep loss on insulin sensitivity is exacerbated when volunteers experience a circadian misalignment. In male participants, the reduction in insulin sensitivity was nearly twice as large when sleep restriction was associated with circadian misalignment than when bedtimes remained fixed, indicating that circadian misalignment has an intrinsic adverse metabolic impact. Irregular sleep schedules that are typical of shift work may thus increase metabolic risk, independently of sleep loss. |
|---|
| responsibles | Béranger, Rossetti |
|---|
| |
|