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Interrelations between sleep and growth hormone (GH) secretion in normal subjects and in patients with GH deficiency| old_uid | 13204 |
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| title | Interrelations between sleep and growth hormone (GH) secretion in normal subjects and in patients with GH deficiency |
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| start_date | 2013/12/17 |
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| schedule | 11h |
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| online | no |
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| location_info | esc. C, 3e étage, salle de réunion équipe Lin |
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| details | Conférence CRNL-WAKING |
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| summary | Pituitary GH secretion is stimulated by hypothalamic GH-releasing hormone. In normal young adults, the 24-h profile of circulating GH levels exhibits stable low levels abruptly interrupted by secretory bursts. The most reproducible GH pulse occurs shortly after sleep onset, concomitantly to the first phase of slow-wave (SW) sleep. A close temporal and quantitative association is consistently observed between SW sleep or SW activity and GH secretion, suggesting that SW sleep is stimulated by hypothalamic GH releasing hormone (GHRH).
In patients with GH deficiency due to a primary pituitary defect, GHRH secretion is likely to be enhanced, because of a lack of negative feedback regulation of GHRH by GH, and duration and intensity of SW sleep are therefore expected to be increased. We investigated a large group of adult GH deficient adults. SW sleep duration and intensity were indeed increased in patients with primary pituitary GH deficiency, and these sleep disturbances were partly reversed by GH replacement therapy. These findings are consistent with a central role of GHRH activity in modulating sleep quality. |
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| responsibles | Béranger, Rossetti |
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