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Neurobiological mechanisms linking early life stress with adult pathological aggression| old_uid | 13227 |
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| title | Neurobiological mechanisms linking early life stress with adult pathological aggression |
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| start_date | 2013/12/20 |
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| schedule | 11h30 |
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| online | no |
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| location_info | salle de conférence CGFB |
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| details | Séminaire FBN. Invité par Katia Touyarot, NutrINeurO |
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| summary | A major risk factor for violence perpetration is childhood exposure to violence, but the neurobiological mechanisms of these long-term effects remain uncertain. Using an animal model devoid of human cultural factors, we find that exposing peripubertal male rats to fear-inducing experiences produced pathological aggression both towards other male conspecifics and towards their female partners during adulthood. Importantly, their offspring also shows increased aggression towards females even without postnatal father-offspring interaction. In searching for key neurobiological mechanisms translating stress effects into increased aggression, we find alterations in amygdala-medial orbitofrontal circuit activity, the testosterone/corticosterone ratio, and the serotonergic system. We also find evidence for a programing role of glucocorticoids and for a link between altered polysialylation of the neural cell adhesion molecule during development and pathological aggression. These findings will be discussed within a broader context reflecting on the societal implications of stress. |
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| responsibles | Deris |
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