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The relationship between spreading depolarization and ictal epileptic activity| old_uid | 13329 |
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| title | The relationship between spreading depolarization and ictal epileptic activity |
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| start_date | 2014/01/27 |
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| schedule | 11h |
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| online | no |
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| location_info | accès ascenseur via Entrée B, 6e étage, amphithéâtre |
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| details | Cycle des conférences CRNL 2014 |
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| summary | Jens Dreier est la référence mondiale pour les CSD (cortical spreading depolarization), auteurs des meilleures publications du domaine et membre fondateur du groupe international COSBID (cooperative group for the study of brain injury depolarizations).
Abstract
In the evolution of the cerebral cortex, the sophisticated organization in a steady state far away from thermodynamic equilibrium has produced the side effect of two fundamental pathological network events: ictal epileptic activity and spreading depolarization. Ictal epileptic activity describes the partial disruption, and spreading depolarization describes the near-complete disruption of the physiological double Gibbs–Donnan steady state. The occurrence of ictal epileptic activity in patients has been known for decades. Recently, unequivocal electrophysiological evidence has been found in patients that spreading depolarizations occur abundantly in stroke and brain trauma. The ion changes can be taken to estimate relative changes in Gibbs free energy from state to state. The calculations suggest that in transitions from the physiological state to ictal epileptic activity to spreading depolarization to death, the cortex releases Gibbs free energy in a stepwise fashion. Spreading depolarization thus appears as a twilight state close to death. Consistently, electrocorticographic recordings in the core of focal ischemia or after cardiac arrest display a smooth transition from the initial spreading depolarization component to the later ultraslow negative potential, which is assumed to reflect processes in cellular death. |
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| responsibles | Béranger, Rossetti |
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