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Dystroglycan is a major organizer of subtypes of GABA synapses| old_uid | 13494 |
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| title | Dystroglycan is a major organizer of subtypes of GABA synapses |
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| start_date | 2014/02/21 |
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| schedule | 11h30 |
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| online | no |
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| location_info | salle de conférence CGFB |
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| details | Séminaire FBN. Une invitation de Maurice Garret, INCIA, Institut de Neurosciences cognitives et intégratives d'Aquitaine |
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| summary | GABAergic inhibition may be “the real essence” in neuronal computation. Practically all neurons in the brain express GABA receptors, which occur in several different subunit combinations and control many crucial aspects of neural function. Changes in GABAergic transmission contribute to the etiology of prominent brain disorders, including epilepsy, anxiety, and schizofrenia. Therefore, the mechanisms that regulate the development and maturation of GABA synapses have important consequences for brain function and disease.
Research over the last two decades has revealed an extraordinary diversity in the anatomical and molecular organization of GABA circuits. We are just starting to appreciate the physiological importance of this diversity, and how it is determined during brain development. In this perspective, I will focus on the evidence that has become available from the analysis of genetic loss-of-function models, i.e. mutant mice lacking crucial molecular constituents of synaptic specializations.
Recent investigations have revealed that proteins in the synaptic cleft act as divalent ligands linking pre- and postsynaptic transmembrane components. Accordingly, the synaptic extracellular matrix can be regarded as the site in which secreted factors and cell adhesion molecules mediate trans-synaptic interactions that may contribute to encode synaptic specificity. An exciting concept emerging from these studies is that GABAergic synaptogenesis depends on multiple pathways, linked into signaling complexes that act synergistically to coordinate synapse development. |
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| responsibles | Deris |
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