|
Molecular mechanisms of functional amyloid formation within endosomes| old_uid | 13860 |
|---|
| title | Molecular mechanisms of functional amyloid formation within endosomes |
|---|
| start_date | 2014/04/17 |
|---|
| schedule | 11h |
|---|
| online | no |
|---|
| location_info | salle 01-02 |
|---|
| details | Séminaire Axe I - Maladies neurodégénératives. Invité par Marie-Claude Potier |
|---|
| summary | Compared to pathological amyloids, functional amyloids are produced in a physiological and regulated manner. During skin pigmentation functional amyloidogenesis requires the cleavage and the sorting of the protein PMEL to intraluminal vesicles of multivesicular endosomes. Our studies, mainly based on electron microscopy approaches, reveal the involvement of beta- and gamma-secretase and of apolipoproteins in PMEL amyloidogenesis. These data not only establish endosomal intraluminal vesicles as the sites of nucleation of functional amyloids but also strengthen the increasing analogies with the molecular mechanisms involved in APP amyloidogenesis during Alzheimer’s disease. |
|---|
| responsibles | Agid |
|---|
| |
|