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Does the content of hippocampal reactivation matter?| old_uid | 14200 |
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| title | Does the content of hippocampal reactivation matter? |
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| start_date | 2017/06/27 |
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| schedule | 15h |
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| online | no |
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| summary | I will present the results of two unpublished projects. The first part, work of Igor Gridchin, involves online identification of cell assemblies and the optogenetic disruption of a selective subgroup of them during reactivation using the Axona recording system. To this end, we trained animals to locate goals in two different environmental context (i.e. two cheeseboards at different location with different distal cues), with each associated with a different goal location. After learning we disrupted the reactivation of assemblies representing one of the goals using our online assembly detection procedure during rest/sleep. Following the disruption we observed a selective memory impairment with the disrupted goal but not with the other.
The second part, work of Haibing Xu, examined reactivated patterns during three different radial 8-arm maze spatial tasks. We found that waking reactivated trajectories at the decision point in the central stem predicted the future arm choice of the animal when the task had a reference memory component but not when it was a pure working memory task. |
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| responsibles | <not specified> |
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