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Synaptic autophagy: a new perspective in Parkinson disease / Candidate à une chaire Bordeaux Neurocampus| old_uid | 14374 |
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| title | Synaptic autophagy: a new perspective in Parkinson disease / Candidate à une chaire Bordeaux Neurocampus |
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| start_date | 2017/09/21 |
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| schedule | 11h |
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| online | no |
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| location_info | Amphi Broca-Nouvelle Aquitaine |
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| details | Invitant : Erwan Bezard, Director of IMN |
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| summary | Synapses are the communication center of the neurons but they are especially vulnerable, since they are located far away from the soma and undergo highly active periods during neuronal communication that can lead to the accumulation of dysfunctional proteins. To ensure synaptic transmission, local synapse specific mechanism take place to cope with proteopathic stress and to restore synaptic homeostasis. Interestingly accumulating evidence places synaptic dysfunction prior to neuronal demise and not surprisingly a rising number of synaptic genes show mutations that cause or influence Parkinson’s disease. Understanding how presynaptic compartments turnover proteins might be crucial to decipher molecular mechanism of the early onset of Parkinson’s disease and potentially provide valuable knowledge to develop “early” biomarkers and specific drugs before irreversible synaptic decay has occurred. I will introduce some unique characteristic of synaptic autophagy, highlight how the synaptic proteins Endophilin-A and Synaptojanin control autophagy and elaborate their role in maintaining synaptic homeostasis and preventing neurodegeneration. |
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| responsibles | Deris |
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