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Gliovascular unit dysfunctions precede neuronal alterations after pediatric brain injury| old_uid | 14735 |
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| title | Gliovascular unit dysfunctions precede neuronal alterations after pediatric brain injury |
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| start_date | 2017/11/03 |
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| schedule | 11h30 |
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| online | no |
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| location_info | Amphi Broca |
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| details | Invitant : Bordeaux Neurocampus / NBA |
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| summary | Traumatic brain injury (TBI) is a major public health issue with at least one million-hospital admissions/year. Mild TBI is defined with a Glasgow coma score > 13, no or transient (< 30 min) loss of consciousness, no major alterations on CT scans and no apparent short-term cognitive deficits. It is now recognized that mild TBI causes significant early and long-term morbidity and is a risk factor for cognitive decline and dementia including Alzheimer Disease. Although TBI hits the pediatric population particularly hard, very little research has been carried out in juvenile models of TBI (jTBI), resulting in limited knowledge regarding its underlying pathophysiological mechanisms, a particularly alarming situation as these mechanisms are different between children and adults. It is critical to have a better understanding of the short- and long-term brain molecular changes in order to accurately develop new drug treatments that could minimize or prevent these long-term cognitive sequelae. |
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| responsibles | Deris |
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