|
Novel functions of oligodendrocytes in axonal| old_uid | 14908 |
|---|
| title | Novel functions of oligodendrocytes in axonal |
|---|
| start_date | 2015/01/12 |
|---|
| schedule | 11h |
|---|
| online | no |
|---|
| details | Conférence de l'ICM. Invité par Brahim Nait Oumesmar |
|---|
| summary | Oligodendrocytes are well known for making myelin to speed up axonal impuls propagation. We found that oligodendrocytes are also required for the functional integrity of long axons in white matter tracts. This neuroprotective function is not only relevant for demyelinating diseases, such as MS, but also for neurodegenerative disorders, in which white matter tracts are affected. One underlying molecular mechanism is the direct support of axonal energy metabolism by 'glycolytic oligodendrocytes', which provide glucose-derived lactate as a fuel for axonal mitochondria. This may be even more necessary as myelin itself isolates the axonal compartment from the outside milieu. Oligodendroglial glucose import and the generation of glycolysis products must be carefully matched to axonal energy needs. Using cell type-specific mouse mutants, we are investigating different mechanisms that may regulate glycolytic behaviour of oligodendrocytes, including axon-to-glia NMDA receptor signaling, the NAD-dependent activation of Sirtuin-2 in oligodendrocytes, and the poorly understood role of N-acetyl-aspartate (NAA) in white matter tracts. |
|---|
| responsibles | Oliviero |
|---|
| |
|