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Adult hippocampal neurogenesis and Alzheimer’s disease: at the crossroads...| old_uid | 14941 |
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| title | Adult hippocampal neurogenesis and Alzheimer’s disease: at the crossroads... |
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| start_date | 2015/01/16 |
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| schedule | 11h |
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| online | no |
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| location_info | Bât. 444, salle de conférences de l'IBAIC |
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| details | Vendredis de Neuro-PSI. Invitée par Valérie Doyère. |
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| summary | New neurons are generated throughout lifetime in the hippocampus of adult mammals. In rodents, increased production of new granule neurons is associated with improved memory capacities, while decreased hippocampal neurogenesis results in impaired memory performance in several memory tasks. In mouse models of Alzheimer’s disease, neurogenesis is impaired and the granule neurons that are generated fail to integrate existing networks. We thus investigated whether endogenous neural stem cells of the diseased brain could be manipulated in order to generate new neurons that could allow cognitive improvement in these mice. |
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| responsibles | Perignon |
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