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From Device Development, to Cell Signaling and Clinical Applications| old_uid | 15409 |
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| title | From Device Development, to Cell Signaling and Clinical Applications |
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| start_date | 2018/02/16 |
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| schedule | 14h30 |
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| online | no |
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| details | Invité par Imad ABOUT |
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| summary | Due to their unique combination of degradation and strength, magnesium based resorbable metal alloys are being explored for many clinical applications such as bone repair and regeneration. Interestingly, the degradation behaviour of these materials is highly sensitive to the local environment, including ion concentrations, fluid flow rate, and pH. In addition, the released Mg ion during device degradation seems to be enhancing bone healing and regeneration. suggesting that magnesium fixation devices may be able to enhance fracture healing. Interestingly, ongoing assessments of a faster degrading magnesium alloy have revealed a dichotomy in the associated biological response. We have observed both regions of bone loss and bone formation around the degrading devices. These in vivo results have provided the rationale to launch a series of mechanistic Mg signalling studies to elucidate the signalling mechanism(s) of Mg on bone and also to develop novel devices for dental application in the field of bone augmentation and regeneration. |
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| responsibles | Fenouil |
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