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Beyond Human Brain Mapping: Predicting Clinical Trajectories for Personalized Medicine| old_uid | 16147 |
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| title | Beyond Human Brain Mapping: Predicting Clinical Trajectories for Personalized Medicine |
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| start_date | 2018/06/18 |
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| schedule | 11h |
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| online | no |
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| summary | Recent years have witnessed an explosion of interest in neuroimaging the human brain and in using it to identify biomarkers for brain-based disease. However, the field generally conceives of neuroimaging as revealing disease-specific activation areas or networks, rather than self-interacting circuits whose trajectories evolve over time. In this talk, we’ll argue that our goals of not only detecting but also predicting disease may require neuroimaging to go beyond brain “mapping,” towards analytic methods grounded in computational neuroscience. We suggest approaches towards understanding the brain that pinpoint key points of failure in circuit regulation which, depending upon how the circuit breaks, may lead to a wide variety of signs and symptoms that cluster as different diagnoses. We’ll look at several examples, discussing: how clinical anxiety and dangerous recklessness may be much more closely related than one might think, how dynamics are constrained by structure in ways that might give insight to our understanding of epilepsy, as well as how a systems-based approach might change our thinking about why some people lose cognitive ability with age. Throughout, we’ll discuss why these newer trends in neuroimaging offer the tantalizing possibility of taking a first step towards personalized medicine with respect to brain-based disease |
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| responsibles | Blancho |
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